N-(3-hydroxyphenyl)-Arachidonoyl amide

An irreversible COX-2 inhibitor

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库存: 现货

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数量
5mg

￥650.00

520.00

- +
10mg

￥1212.00

970.00

- +
50mg

￥5100.00

4080.00

- +
100mg

￥8925.00

7140.00

- +

已选 0 种 0 瓶

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货号: ajci14986
CAS: 183718-75-4
别名: 3-HPAA
分子式: C26H37NO2
分子量: 395.6
纯度: >98%
溶解度: ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
储存: Store at -20°C
库存: 现货

Background

IC50: 2 μM

N-(3-hydroxyphenyl) -Arachidonoyl amide, also known as 3-HPAA, is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide. 3-HPAA, metabolized by both cyclooxygenase (COX) -1 and COX-2, is an irreversible and selective inhibitor of COX-2 with an IC50 value of 2 M. 3-HPAA can be efficiently oxygenated to prostaglandin and hydroxyeicosatetraenoate products by prostaglandin endoperoxide synthase (PGHS) -2. It appears that 3-HPAA can be converted by PGHS-1 in a similar manner.

COX enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. COX enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them clinically important [1]. COX-2, overexpressed in cancer cells, promotes tumorigenesis and induces neo-angiogenesis. Additionally, it plays an important role in inflammation and pyrexia.

In vitro: Up to now, in vitro study of 3-HPAA is still in the development stage.

In vivo: Up to now, in vivo study of 3-HPAA is still in the development stage.

Reference:
[1].? Fitzpatrick, F. Cyclooxygenase Enzymes: Regulation and Function. Current Pharmaceutical Design. 2004; 10(6): 577-588.