3-Bromopyruvic acid

An alkylating agent and antimetabolite of pyruvate

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1g

￥450.00

360.00

- +
5g

￥512.00

410.00

- +
10g

￥662.00

530.00

- +
25g

￥1412.00

1130.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci15288
CAS: 1113-59-3
别名: 3-溴丙酮酸; Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP
分子式: C3H3BrO3
分子量: 166.96
纯度: >98%
溶解度: ≥ 16.7mg/mL in Water
储存: Store at 2-8°C
库存: 现货

Background

3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells.Target: hexokinase II in vitro: 3-BrPA dissociates HK II from this complex, causing cell death, and thus, having an anti-tumor effect. In vitro treatment of cells with 3-BrPA significantly inhibited their growth, as evaluated by MTT assay and adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA). [1] 3-Bromopyruvic acid (3-BP) is a glycolytic inhibitor and a promising anticancer compound, induces oxidative stress and depletes cells of glutathione (GSH). [2]in vivo: 3-BrPA treatment (50 mg/kg ip. daily, 6 days/week for three weeks) is effective in the animal model by attenuating tumor growth and causing tumor necrosis. Toxic signs were not observed. The acute toxicity study provided an LD50 of 191.7 mg/kg for 3-BrPA. [1]

参考文献:
[1]. Gong L, et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings. Anticancer Agents Med Chem. 2014 Jun;14(5):771-6.
[2]. Sadowska-Bartosz I, et al. Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione. Pharmacol Rep. 2016 Apr;68(2):502-5.