(6-)ε-Aminocaproic acid

An inhibitor of plasmin activating enzymes

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货号: ajci16182
CAS: 60-32-2
别名: 氨基己酸; EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid
分子式: C6H13NO2
分子量: 131.17
纯度: >98%
溶解度: H<sub>2</sub>O : ≥ 50 mg/mL (381.18 mM); DMSO : 1 mg/mL (7.62 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

6-Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.Target: Others6-aminohexanoic acid is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. Aminocaproic acid is also an intermediate in the polymerization of Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam.Aminocaproic acid is used to treat excessive postoperative bleeding, especially after procedures in which a great amount of bleeding is expected, such as cardiac surgery. Aminocaproic acid can also be used to treat the overdose and/or toxic effects of the thrombolytic pharmacologic agents tissue plasminogen activator and streptokinase [1, 2].

参考文献:
[1]. Gardner, F.H. and R.E. Helmer, 3rd, Aminocaproic acid. Use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia. JAMA, 1980. 243(1): p. 35-7.
[2]. Schwartz, B.S., et al., Epsilon-aminocaproic acid in the treatment of patients with acute promyelocytic leukemia and acquired alpha-2-plasmin inhibitor deficiency. Ann Intern Med, 1986. 105(6): p. 873-7.