PD 153035

A potent EGFR kinase inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥162.00

130.00

- +
5mg

￥612.00

490.00

- +
10mg

￥812.00

650.00

- +
25mg

￥2175.00

1740.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci16208
CAS: 153436-54-5
别名: 4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉,SU-5271; AG1517; ZM 252868
分子式: C16H14BrN3O2
分子量: 360.2
纯度: >98%
溶解度: DMF: 0.3 mg/ml,DMSO: 2 mg/ml,DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml,Ethanol: 0.2 mg/ml
储存: -20°C
库存: 现货

Background

PD 153035 is a potent, reversible inhibitor of EGFR kinase (K_i = 5.2 pM; IC₅₀ = 29 pM).¹ It less effectively inhibits HER2 (IC₅₀ = 2.3 µM) and has little effect on several other receptor and non-receptor tyrosine kinases.¹ PD 153035 has been shown to rapidly suppress autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.^2,3

1.Fry, D.W., Kraker, A.J., McMichael, A., et al.A specific inhibitor of the epidermal growth factor receptor tyrosine kinaseScience265(5175)1093-1095(1994) 2.Bos, M., Mendelsohn, J., Kim, Y.M., et al.PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent mannerClinical Cancer Research3(11)2099-2106(1997) 3.Rae, J.M., and Lippman, M.E.Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitorsBreast Cancer Research and Treatment83(2)99-107(2004)