Spinosyn A

A naturally-occurring insecticide

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1mg

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货号: ajci16406
CAS: 131929-60-7
别名: 多杀霉素 A
分子式: C41H65NO10
分子量: 732
纯度: >98%
溶解度: DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存: Store at -20°C
库存: 现货

Background

Spinosyn A is an insect nicotinic acetylcholinesterase receptors (nAChRs) agonist and potent insecticide.

The spinosyns are a family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa. Spinosyn A is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide.

In vitro: The mixture of spinosyns A and D, a commercial insecticide TracerTM (DowAgroSciences), is useful against various crop pests such as tobacco budworm. It was found that the deoxy analogs of spinosyns A were more potent insecticides than their respective parent factor. Moreover, the 2’-desmethoxy analogs of spinosyns A showed insecticidal potency against H. virescens greater than that of spinosyns A and D, suggesting that polarity was not well tolerated. Furthermore, the activity of 3'-deoxy spinosyn J was about the same as spinosyn A, and the activity of 2'-deoxy spinosyn H was found to be slightly greater than that of spinosyn A [1].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] L.? C. Creemer, H. A. Kirst, J. W. Paschal, et al. Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety. J.Antibiot.(Tokyo) 53(2), 171-178 (2000).