DGAT-1 inhibitor

A DGAT-1 inhibitor

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库存: 现货

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数量
5mg

￥937.00

750.00

- +
10mg

￥1625.00

1300.00

- +
25mg

￥3600.00

2880.00

- +
50mg

￥6487.00

5190.00

- +
100mg

￥11050.00

8840.00

- +

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货号: ajci16508
CAS: 701232-20-4
别名: 反式-4-[4-(4-氨基-7,7-二甲基-7H-嘧啶并[4,5-B][1,4]噁唑-6-基)苯基]-环己基乙酰胺
分子式: C22H26N4O3
分子量: 394.2
纯度: >98%
溶解度: ≥ 39.4 mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.

参考文献:
[1]. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.
[2]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5.
[3]. Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(7):2433-46.