Carboxy-PTIO, potassium salt

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

可选规格

包装

价格

促销价

数量
5mg

￥630.00

504.00

- +
10mg

￥1117.00

893.00

- +
50mg

￥4494.00

3595.00

- +
100mg

￥7852.00

6281.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase

货号：ajci16664
CAS：148819-94-7
分子式：C14H16KN2O4
分子量：315.38
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Carboxy-PTIO，是一种常用的一氧化氮清除剂，可以用于抑制一氧化氮信号通路。本Carboxy-PTIO为钾盐(Carboxy-PTIO ， potassium salt)。carboxy-PTIO 可以和NO反应生成carboxy-PTI衍生物，同时产生亚硝酸盐或硝酸盐，从而起到清除NO 的作用。

Carboxy-PTIO水溶性很好，溶解度大于20 mg/ml，可溶于一些常见缓冲液如PBS等，也可溶于无水乙醇、甲醇、DMSO、二甲基甲酰胺。

Carboxy-PTIO常见使用浓度为0.1-10mM。实际的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。

参考文献：

1. He H, Feng YS, Zang LH, Liu WW, Ding LQ, Chen LX, Kang N, Hayashi T, Tashiro S, Onodera S, Qiu F, Ikejima T. Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells. Food Chem Toxicol. 2014 Sep;71:128-35.

2. Han Y, Jiang Q, Gao H, Fan J, Wang Z, Zhong F, Zheng Y, Gong Z, Wang C. The Anti-apoptotic Effect of Polypeptide from Chlamys farreri (PCF) in UVB-Exposed HaCaT Cells Involves Inhibition of iNOS and TGF-β1. Cell Biochem Biophys. 2015 Mar;71(2):1105-15.

3. Zhang L, Ren X, Chen Y, Gao Y, Wang N, Lu Z, Gao L, Qin L, Wang Y, Gao H, Li K, Jiang L, Cui H, Liu C, Zhang Y, Qi X, Wang X. Chondroitin sulfate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus via interaction with the capsid protein VP2. Viruses. 2015 Mar 23;7(3):1474-91.

4. Song LJ, Luo H, Fan WH, Wang GP, Yin XR, Shen S, Wang J, Jin Y, Zhang W, Gao H, Liu Q, Wang WL, Feng B, Yu CX. Oxadiazole-2-oxides may have other functional targets, in addition to SjTGR, through which they causemortality in Schistosoma japonicum. Parasit Vectors. 2016 Jan 20;9:26.

5. Guo Y, Deng Y, Huang Z, Luo Q, Peng Y, Chen J, Jiang H, Ye J, Li J. EBP50 induces apoptosis in macrophages by upregulating nitric oxide production to eliminate intracellularMycobacterium tuberculosis. Sci Rep. 2016 Jan 5;6:18961.

6. An XZ, Zhao ZG, Luo YX, Zhang R, Tang XQ, Hao D, Zhao X, Lv X, Liu D. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016 Apr 26;7(17):24719-33.