Finasteride

An inhibitor of 5α-reductase type II

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
100mg

￥462.00

370.00

- +
200mg

￥700.00

560.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci16738
CAS: 98319-26-7
别名: 非那雄胺; MK-906
分子式: C23H36N2O2
分子量: 372.54
纯度: >98%
溶解度: ≥ 14.65 mg/mL in DMSO, ≥ 76.4 mg/mL in EtOH
储存: Store at -20°C
库存: 现货

Background

Finasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM). Target: 5-alpha ReductaseApproved: 1992Finasteride, a synthetic 4-azasteroid antiandrogen compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). Finasteride is used in the treatment of prostate cancer, benign prostatic hyperplasia, and androgenetic alopecia (male pattern baldness). In benign prostatic hyperplasia, finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10 nM, significantly lower than in stroma (Ki = 33nM) [1].

参考文献:
[1]. Weisser, H. and M. Krieg, In vitro inhibition of androstenedione 5alpha-reduction by finasteride in epithelium and stroma of human benign prostatic hyperplasia. J Steroid Biochem Mol Biol, 1998. 67(1): p. 49-55.