Dapsone

An anti-inflammatory, antimalarial, and antibacterial compound

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1mg

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货号: ajci16854
CAS: 80-08-0
别名: 氨苯砜; 4,4′-Diaminodiphenyl sulfone; DDS
分子式: C12H12N2O2S
分子量: 248.3
纯度: >98%
溶解度: ≥ 8.35mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Target: AntibacterialDapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects [1]. As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Dapsone has anti-inflammatory and immunomodulatory effects [2].

参考文献:
[1]. Diaz-Ruiz, A., et al., Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J Neurosci Res, 2008. 86(15): p. 3410-9.
[2]. Begon, E., O. Chosidow, and P. Wolkenstein, [Disulone]. Ann Dermatol Venereol, 2004. 131(12): p. 1062-73.