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  • TMCB
TMCB的可视化放大

TMCB

A dual inhibitor of CK2 and ERK8

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TMCB的二维码
  • 库存: 现货
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  • 包装
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    促销价
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  • 5mg
    ¥962.00
    770.00
    - +
  • 10mg
    ¥1700.00
    1360.00
    - +
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  • 货号: ajci17068
  • CAS: 905105-89-7
  • 别名: 4,5-二氢-N-(2,3,5,6-四溴-4-甲氧基苯基)-1H-咪唑-2-甲酰胺
  • 分子式: C11H9Br4N3O2
  • 分子量: 534.82
  • 纯度: >98%
  • 溶解度: 25mM in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

TMCB is a dual inhibitor of casein kinase 2 (CK2) and ERK8 (IC50 = 0.5 μM for both).[1] It also binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 μM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 μM. TMCB induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 μM.


Reference:
[1]. Pagano, M.A., Bain, J., Kazimierczuk, Z., et al. The selectivity of inhibitors of protein kinase CK2: An update. Biochem. J. 415(3), 353-365 (2008).

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