Ticlopidine hydrochloride

A P2Y12 receptor antagonist with antiplatelet activity

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库存: 现货

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500mg

￥437.00

350.00

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1g

￥550.00

440.00

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5g

￥987.00

790.00

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货号: ajci17234
CAS: 53885-35-1
别名: 盐酸噻氯匹定
分子式: C14H15Cl2NS
分子量: 300.25
纯度: >98%
溶解度: DMSO : 50 mg/mL (166.53 mM; Need ultrasonic)
储存: 4°C, away from moisture
库存: 现货

Background

Ticlopidine is a thienopyridine P2Y₁₂ receptor antagonist.¹ It inhibits aggregation of human platelets induced by collagen, arachidonic acid , and ADP .² It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.³ Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.⁴ Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.

1.Porto, I., Giubilato, S., De Maria, G.L., et al.Platelet P2Y12 receptor inhibition by thienopyridines: Status and futureExpert Opin. Investig. Drugs18(9)1317-1332(2009) 2.Bruno, J.J.The mechanisms of action of ticlopidineThromb. Res. Suppl.459-67(1983) 3.Sugidachi, A., Asai, F., Ogawa, T., et al.The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist propertiesBr. J. Pharmacol.129(7)1439-1446(2000) 4.Ma, L., Elliott, S.N., Cirino, G., et al.Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor releaseProc. Natl. Acad. Sci. USA98(11)6470-6475(2001)