Darunavir

An HIV-1 protease inhibitor

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库存: 现货

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5mg

￥575.00

460.00

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50mg

￥2425.00

1940.00

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货号: ajci17446
CAS: 206361-99-1
别名: 达芦那韦; TMC114; UIC-94017
分子式: C27H37N3O7S
分子量: 547.66
纯度: >98%
溶解度: ≥ 22.65mg/mL in DMSO, ≥ 4.94 mg/mL in EtOH with ultrasonic
储存: Store at -20°C
库存: 现货

Background

Darunavir is an orally-bioavailable non-peptidic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that selectively inhibits HIV-1 protease enzyme induced cleavage of gag and gag-pol poly-proteins preventing the maturation of virions and also inhibits the dimerization of HIV-1 protease suppressing proteolytic activity and subsequent replication of HIV-1. Study results have shown that darunavir exhibits potent inhibition against HIV-1 with a value of 50% inhibition concentration IC₅₀ of 0.003 μmol/L in HIV-1 infected MT-2 cells. Darunavir binds to HIV-1 protease with considerably high affinity and fits closely with the substrate envelop leading to its potent ability to inhibit multidrug-resistant HIV strains.

Reference

?[1].McKeage K, Perry CM, Keam SJ. Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503. doi: 10.2165/00003495-200969040-00007.