Kif15-IN-1

Kif15-IN-1 是有丝分裂驱动蛋白家族成员 15 (Kif15) 的抑制剂，用于细胞增殖性疾病的研究。

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库存: 现货

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5mg

￥3087.00

2470.00

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10mg

￥4625.00

3700.00

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50mg

￥12762.00

10210.00

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100mg

￥17762.00

14210.00

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货号: ajci17448
CAS: 672926-32-8
别名: 2-[[(2S)-2-(1,4-二氢-2,4-二氧代-3(2H)-喹唑啉基)-3-甲基-1-氧代丁基]氨基]-4-甲基-5-噻唑羧酸乙酯
分子式: C20H22N4O5S
分子量: 430.48
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

Kif15-IN-1, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].

Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with KIF11 [3].

参考文献:
[1].?Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2].? Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3].? Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.