HX 531

An RXR antagonist

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库存: 现货

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数量
1mg

￥537.00

430.00

- +
5mg

￥1125.00

900.00

- +
10mg

￥1675.00

1340.00

- +
25mg

￥3650.00

2920.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci17870
CAS: 188844-34-0
别名:
分子式: C29H29N3O4
分子量: 483.56
纯度: >98%
溶解度: 0.12mg/mL in ethanol, 10mg/mL in DMSO, 15mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid -induced transactivation of RXR.[1] It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.[2]

Reference:
[1]. Konta, T., Xu, Q., Furusu, A., et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J. Biol. Chem. 276(16), 12697-12701 (2001).
[2]. Yamauchi, T., Waki, H., Kamon, J., et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J. Clin. Invest. 108(7), 1001-1013 (2001).