K 114

K 114 是一种荧光刚果红类似物，与淀粉样蛋白原纤维紧密结合，EC50 为 20-30 nM。

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库存: 现货

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数量
10mg

￥2412.00

1930.00

- +
50mg

￥9987.00

7990.00

- +

已选 0 种 0 瓶

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货号: ajci18012
CAS: 872201-12-2
别名: (反,反)-1-溴-2,5-双(4-羟基)乙烯基苯
分子式: C22H17BrO2
分子量: 393.27
纯度: >98%
溶解度: <39.33mg/ml in DMSO; <19.66mg/ml in ethanol
储存: Store at -20°C
库存: 现货

Background

K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI)[2].

K114's unusually low buffer fluorescence is due to self-quenching in sedimentable aggregates or micelles which upon interacting with amyloid fibrils undergo an enhancement in fluorescence intensity and shifts in the excitation and emission spectra[1].

参考文献:
[1]. LeVine H 3rd, et al. Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry. 2005 Dec 6;44(48):15937-43.
[2]. Selmani V, et al. K114 (trans, trans)-bromo-2,5-bis(4-hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils. Protein Sci. 2015 Mar;24(3):420-5.