PSI-6206

An inactive derivative of a HCV NS5B inhibitor

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库存: 现货

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5mg

￥0.00

0.00

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10mg

￥650.00

520.00

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25mg

￥0.00

0.00

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50mg

￥1962.00

1570.00

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货号: ajci18044
CAS: 863329-66-2
别名: (2'R)-2'-脱氧-2'-氟-2'-甲基脲苷,RO 2433; GS-331007
分子式: C10H13FN2O5
分子量: 260.22
纯度: >98%
溶解度: ≥ 13.1mg/mL in DMSO, ≥ 24.15 mg/mL in EtOH with ultrasonic, ≥ 48.7 mg/mL in Water with ultrasonic
储存: Store at -20°C
库存: 现货

Background

PSI-6206 (as known as RO-2433 or GS-331007), β-_D-2’-deoxy-2’-fluoro-2’-C-methyluridine, is the deaminated derivative of PSI-6130, β-_D-2’-deoxy-2’-fluoro-2’-C-methylcytidine, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system.? PSI-6206, itself, does not shown any inhibitory activity towards HCV replication in the HCV subgenomic replicon system. However, the its triphosphate form, RO2433-TP, is a potent inhibitor of RNA synthesis by HCV polymerase, which inhibits both the RNA sysnthesis activity of HCV replicase (IC₅₀ = 1.19 uM) and the RNA synthesis activity of the recombinant HCV Con1 NS58 on a heteropolymeric RNA template derived from the 3’-end of the negative strand of the HCV genome (IC₅₀ = 0.52 uM and K_i = 0.141 uM).

Reference

[1].Han Ma, Wen-Rong Jiang, Nicole Robledo, Vincent Leveque, Samir Ali, Teresa Lara-Jamie, Mohammad Masjedizadeh, David B. Smith, Nick Cammack, Klaus Klumpp, and Julian Symons. Characterization of the metabolic ctivation of hepatitis C virus nucleoside inhibitor β-_D-2’-deoxy-2’-fluoro-2’-C-methylcytidine (PSI-6130) and identification of a novel active 5’-triphosphate species. The Journal of Biological Chemistry 2007; 282(41): 29812-29820