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  • OF-1
OF-1的可视化放大

OF-1

A bromodomain probe for BRPF proteins

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OF-1的二维码
  • 库存: 现货
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  • 5mg
    ¥612.00
    490.00
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  • 25mg
    ¥2150.00
    1720.00
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  • 100mg
    ¥4875.00
    3900.00
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  • 货号: ajci19206
  • CAS: 919973-83-4
  • 别名:
  • 分子式: C17H18BrN3O4S
  • 分子量: 440.31
  • 纯度: >98%
  • 溶解度: ≥ 14.55mg/mL in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd value = 100nM and 500 nM, respectively; >100-fold selectivity over majority of other bromodomains).
BRPF (BRomodomain and PHD Finger containing) protein family are scaffolding proteins that assembles MYST histone acetyltransferase complexes. MYST complexes play important role in DNA repair, recombination, replication and transcription activation.
In cellular thermal shift assay (CETSA) of full length BRPF1B, OF-1 enhanced thermal stability at 1 μM. In BRPF2 FRAP assay, OF-1 showed accelerated FRAP recovery at 5μM. OF-1 exhibited modest general cytotoxicity.
参考文献:
[1]. OF-1 - A chemical probe for BRPF bromodomains. (2010, October 13). SGC. Retrieved from http://www.thesgc.org/chemical-probes/OF-1

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