Cyclo (-RGDfK)

An inhibitor of αvβ3 integrin

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库存: 现货

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5mg

￥987.00

790.00

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25mg

￥3137.00

2510.00

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100mg

￥6137.00

4910.00

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货号: ajci19462
CAS: 161552-03-0
别名: Cyclo(-Arg-Gly-Asp-D-Phe-Lys)
分子式: C27H41N9O7
分子量: 603.7
纯度: >98%
溶解度: ≥ 30.185mg/mL in DMSO, ≥ 59.2 mg/mL in Water
储存: Store at -20°C
库存: 现货

Background

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM.

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].

参考文献:
[1]. Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95.
[2]. Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.