Vanoxerine dihydrochloride

An inhibitor of dopamine uptake

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥425.00

340.00

- +
25mg

￥937.00

750.00

- +
50mg

￥1600.00

1280.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci19724
CAS: 67469-78-7
别名: 伐诺司林二盐酸盐,GBR-12909 dihydrochloride; I893 dihydrochloride
分子式: C28H34Cl2F2N2O
分子量: 523.49
纯度: >98%
溶解度: DMF: 2 mg/ml,DMSO: 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

Vanoxerine is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM [1].

As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases. Vanoxerine is also found to have desirable cardiac antiarrhythmic properties. It is a blocker of cardiac hERG (hKv11.1) with IC50 value of 0.84nM. It also blocks the ICa,L and hNav1.5 channel with IC50 values of 320nM and 830nM, respectively. Vanoxerine does not significantly prolong Purkinje fiber APD60 and APD90 and has no significant effect on QT or TDR. Further, the clinical trial demonstrates that the effective concentrations of vanoxerine are well tolerated and safe in man [2].

参考文献:
[1] Giros B, el Mestikawy S, Godinot N, Zheng K, Han H, Yang-Feng T, Caron MG. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol Pharmacol. 1992 Sep;42(3):383-90.
[2] Lacerda AE, Kuryshev YA, Yan GX, Waldo AL, Brown AM. Vanoxerine: cellular mechanism of a new antiarrhythmic. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10.