NFAT Inhibitor

A peptide inhibitor of NFAT

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库存: 现货

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数量
1mg

￥762.00

610.00

- +
5mg

￥3050.00

2440.00

- +
10mg

￥5500.00

4400.00

- +
25mg

￥10687.00

8550.00

- +

已选 0 种 0 瓶

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货号: ajci20174
CAS: 249537-73-3
别名: VIVIT peptide
分子式: C75H118N20O22S
分子量: 1683.93
纯度: >98%
溶解度: ≥ 179.9 mg/mL in DMSO with ultrasonic, <8.44 mg/mL in EtOH, ≥ 34.54 mg/mL in Water with ultrasonic
储存: Store at -20°C
库存: 现货

Background

NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].

NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9[2].

参考文献:
[1]. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33.
[2]. Ma JD, et al. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Aug;71(8):1252-1264.