Kif15-IN-2

Kif15-IN-2 是有丝分裂驱动蛋白 Kif15 的抑制剂，用于细胞增殖性疾病的研究。

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库存: 现货

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数量
2mg

￥1987.00

1590.00

- +
5mg

￥3037.00

2430.00

- +
10mg

￥4225.00

3380.00

- +
50mg

￥13775.00

11020.00

- +
100mg

￥19537.00

15630.00

- +

已选 0 种 0 瓶

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货号: ajci20230
CAS: 672926-33-9
别名: (ALPHAS)-1,4-二氢-ALPHA-异丙基-N-[4-甲基-5-(5-甲基-1,3,4-恶二唑-2-基)-2-噻唑基]-2,4-二氧代-3(2H)-喹唑啉乙酰胺
分子式: C20H20N6O4S
分子量: 440.48
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

Kif15-IN-2, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].

Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withKIF11 [3].

参考文献:
[1].?Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2].? Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3].? Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.