TUG 891

A FFAR4 agonist

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库存: 现货

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促销价

数量
5mg

￥962.00

770.00

- +
10mg

￥1575.00

1260.00

- +
25mg

￥3212.00

2570.00

- +
50mg

￥5500.00

4400.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci20388
CAS: 1374516-07-0
别名:
分子式: C23H21FO3
分子量: 364.41
纯度: >98%
溶解度: ≥ 72.8 mg/mL in DMSO, ≥ 18.7 mg/mL in EtOH with ultrasonic, ≥ 1.82 mg/mL in Water with ultrasonic and warming
储存: Store at RT
库存: 现货

Background

TUG-891is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].

参考文献:
[1]. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25