Ivachtin

A reversible caspase-3 inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥975.00

780.00

- +
5mg

￥2862.00

2290.00

- +
10mg

￥4737.00

3790.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci20516
CAS: 745046-84-8
别名: Caspase-3 Inhibitor VII
分子式: C20H21N3O7S
分子量: 447.46
纯度: >98%
溶解度: DMF: 2.5 mg/mL,DMF:PBS (pH7.2) (1:30): 0.03 mg/mL,DMSO: slightly soluble
储存: Desiccate at 4°C
库存: 现货

Background

Ivachtin is a potent inhibitor of caspase-3 with IC50 value of 23 nM [1].

Caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. Sequential activation of caspases plays an important role in cell apoptosis.

Ivachtin is a potent and reversible inhibitor of caspase-3 in a noncompetitive way. Ivachtin was the most potent inhibitor against caspase-3, but the selectivity versus the remaining caspases was modest. In human Jurkat T cells treated with 10 μM staurosporin, Ivachtin protected cells in a higher level, which suggested that Ivachtin had a good cell permeability and antiapoptotic activity [1].

Reference:
[1].?Kravchenko DV, Kuzovkova YA, Kysil VM, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem, 2005, 48(11): 3680-3683.