Marinobufagenin

An α1 Na+/K+ ATPase sodium pump inhibitor

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库存: 现货

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数量
500ug

￥812.00

650.00

- +
1mg

￥1537.00

1230.00

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5mg

￥6712.00

5370.00

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货号: ajci20620
CAS: 470-42-8
别名: 南美蟾毒精
分子式: C24H32O5
分子量: 400.5
纯度: >98%
溶解度: DMF: 3 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml,Ethanol: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals. MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension. Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure. Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.