Bicyclol

A hepatoprotective agent

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库存: 现货

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1mg

￥0.00

0.00

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5mg

￥662.00

530.00

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10mg

￥1125.00

900.00

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货号: ajci20850
CAS: 118159-48-1
别名: 双环醇; SY801
分子式: C19H18O9
分子量: 390.3
纯度: >98%
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Bicyclol is a hepatoprotective agent.,,, It has antiviral activity against hepatitis B (HBV), reducing viral DNA and the secretion of the HBV antigens HBsAg and HBeAg by 59 and 35%, respectively, in infected 2.2.15 HepG2 cells. In vivo, bicyclol reduces duck HBV (DHBV) DNA in DHBV-infected ducks at doses >=0.4 g/kg. It also reduces the expression of TNF-α and the accumulation of lymphocytes in the liver in a mouse model of liver injury induced by concanavalin A . Oral administration of bicyclol prior to injection of diethylnitrosamine (DEN) and phenobarbital prevents formation of DEN/PB-induced hepatocellular carcinomas. It also reduces liver fibrosis in a rat model of bile duct ligation-induced hepatic fibrosis.