Picotamide

An antiplatelet drug

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库存: 现货

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数量
5mg

￥1037.00

830.00

- +
10mg

￥1837.00

1470.00

- +
25mg

￥4025.00

3220.00

- +
50mg

￥7075.00

5660.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci20888
CAS: 32828-81-2
别名: 吡考胺
分子式: C21H20N4O3
分子量: 376.4
纯度: >98%
溶解度: 1mg/mL in ethanol, 5mg/ml in DMSO, 10mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

Picotamide is an antiplatelet drug that inhibits both thromboxane A2 (TXA2) receptors (Kd = 325 nM) and TXA2 synthase.[1] [2]? It significantly inhibits basal and lipopolysaccharide-stimulated TXA2 synthesis by rat peritoneal macrophages when used at 0.5 mM.[3] Formulations containing picotamide have potential applications in the reduction of peripheral artery disease in patients with diabetes.[1]

Reference:
[1]. Celestini, A., and Violi, F. A review of picotamide in the reduction of cardiovascular events in diabetic patients. Vasc. Health Risk Manag. 3(1), 93-98 (2008).
[2]. Modesti, P.A., Cecioni, I., Colella, A., et al. Binding kinetics and antiplatelet activities of picotamide, a thromboxane A2 receptor antagonist. Br. J. Pharmacol. 112(1), 81-86 (1994).
[3]. Matera, G., Chisari, M., Altavilla, D., et al. Selective thromboxane synthetase inhibition by picotamide and effects on endotoxin-induced lethality. Proc. Soc. Exp. Biol. Med. 187(1), 58-61 (1988).