Prostaglandin F2α methyl ester

A PGF2α analog with ocular hypotensive activity

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500ug

￥537.00

430.00

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1mg

￥1025.00

820.00

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5mg

￥4100.00

3280.00

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10mg

￥7200.00

5760.00

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货号: ajci20982
CAS: 33854-16-9
别名: 地诺前列素甲酯
分子式: C21H36O5
分子量: 368.5
纯度: >98%
溶解度: DMF: 35 mg/ml,DMSO: 35 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS (pH 7.2) (1:4): 0.4 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin F2α methyl ester (PGF2α methyl ester) is an analog of PGF2α in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2α methyl ester was one of the first PG esters shown to have ocular hypotensive activity. This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF2α. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 ug dose of PGF2α-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.