Alternariol monomethyl ether

A mycotoxin

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1mg

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5mg

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货号: ajci21116
CAS: 23452-05-3
别名: 交链孢霉甲基醚
分子式: C15H12O5
分子量: 272.3
纯度: >98%
溶解度: Dichloromethane: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 μg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 μM in HCT116 cells). It inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 μM, respectively. AME selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 μM). AME also provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis.