Sulochrin

A fungal metabolite with antiallergenic, anti-angiogenic, and antiviral activity

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1mg

￥3287.00

2630.00

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5mg

￥12112.00

9690.00

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货号: ajci21148
CAS: 519-57-3
别名: 硫赭曲菌素
分子式: C17H16O7
分子量: 332.3
纯度: >98%
溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

Sulochrin is a fungal metabolite produced by A. terreus and Penicillium that exhibits antiallergenic, anti-angiogenic, and antiviral activities. Sulochrin inhibits eosinophil degranulation. It prevents leukotriene C4 (LTC4) release, O2- production, and IL-8 production (IC50s = 0.03, 8.2, 9.6, and 8.7 μM, respectively) and inhibits migration of human and guinea pig eosinophils (IC50 = 0.2-0.4 μM). Sulochrin inhibits VEGF-induced capillary tube formation of human umbilical vein endothelial cells (HUVEC) in vitro (70% inhibition at 10 mg/ml). It also inhibits hepatitis C viral infection (IC50 = 24.4 μM) in vitro.