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  • Digoxigenin Monodigitoxoside
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Digoxigenin Monodigitoxoside

A Na+/K+-ATPase inhibitor

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Digoxigenin Monodigitoxoside的二维码
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  • 500ug
    ¥3512.00
    2810.00
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  • 1mg
    ¥5750.00
    4600.00
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  • 货号: ajci21152
  • CAS: 5352-63-6
  • 别名: 地高辛杂质D
  • 分子式: C29H44O8
  • 分子量: 520.7
  • 纯度: >98%
  • 溶解度: DMSO: slighly soluble,Methanol: slighly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Digoxigenin monodigitoxoside is a Na+/K+-ATPase inhibitor and cardiac glycoside metabolite of digoxin . It has a binding affinity of 0.829 and an inhibitory potency of 1.07 relative to [3H]ouabain in a competitive binding assay using purified lamb Na+/K+-ATPase and for its ATPase activity, respectively. Digoxigenin monodigitoxoside is selective for the α3β1 isoform over α1β1 and α2β1 (Kds = 31.8, 65, and 35 nM, respectively). Digoxigenin monodigitoxoside produces a more potent inotropic response in perfused guinea pig hearts than digoxin with 60 and 46% increases in inotropy, respectively.

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