Terrein

A fungal metabolite with diverse biological activities

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库存: 现货

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数量
1mg

￥2037.00

1630.00

- +
5mg

￥7150.00

5720.00

- +
10mg

￥11212.00

8970.00

- +

已选 0 种 0 瓶

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Background

Terrein is a fungal metabolite produced by A. terreus with diverse biological activities. It reduces melanin production in Mel-Ab mouse melanocytes in a dose-dependent manner via ERK activation and downregulation of microphthalmia-associated transcription factor (MITF). Terrein inhibits proliferation of human keratinocytes and thins the epidermis in a skin equivalent model of psoriasis vulgaris. It is antimicrobial, inhibiting the growth of S. aureus, A. hydrophila, E. faecalis, A. flavus, A. alternata, B. sorokiniana, and P. drechsleri (MICs = 1-40 μg/ml). Terrein also inhibits growth of A549 lung cancer cells in a dose-dependent manner.