Retro-2

A selective inhibitor of retrograde protein trafficking mediated by syntaxin-5

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥925.00

740.00

- +
10mg

￥1525.00

1220.00

- +
50mg

￥4525.00

3620.00

- +
100mg

￥7337.00

5870.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci21212
CAS: 1429192-00-6
别名: RN 1-001
分子式: C19H16N2OS
分子量: 320.4
纯度: >98%
溶解度: DMSO : ≥ 125 mg/mL (390.13 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C, protect from light
库存: 现货

Background

Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 uM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 uM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 uM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.