N-Arachidonoyl Dopamine

An arachidonoyl amino acid and CB1 receptor agonist

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库存: 现货

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5mg

￥900.00

720.00

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10mg

￥1662.00

1330.00

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50mg

￥6912.00

5530.00

- +
100mg

￥10875.00

8700.00

- +

已选 0 种 0 瓶

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货号: ajci21254
CAS: 199875-69-9
别名: NADA
分子式: C28H41NO3
分子量: 439.6
纯度: >98%
溶解度: 0.1 M Na2CO3: Colloidal suspension @ <100 μ g,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,Ethanol:PBS (1:1): 100 μ g/ml (colloidal suspensio
储存: Store at -20°C
库存: 现货

Background

Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA), have been isolated and characterized from bovine brain. NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA). NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 uM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.