S-(2,4-Dinitrophenyl)-Glutathione

A substrate for glutathione-S-transferase

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库存: 现货

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数量
1mg

￥825.00

660.00

- +
5mg

￥3612.00

2890.00

- +
10mg

￥6012.00

4810.00

- +

已选 0 种 0 瓶

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货号: ajci21270
CAS: 26289-39-4
别名: S-(2,4二硝基苯基)-谷胱甘肽,Dinitrophenyl-S-Glutathione
分子式: C16H19N5O10S
分子量: 473.4
纯度: >98%
溶解度: Slightly soluble in water
储存: Store at -20°C
库存: 现货

Background

S-(2,4-Dinitrophenyl)-glutathione is a substrate for glutathione-S-transferase with a kinetic dissociation constant of 7 uM. [1]? In vitro, it is transported by multidrug resistance protein 1 (MDR1) and MDR3, which are transporters that confer resistance to some chemotherapeutics.[2]?

Reference:
[1]. Schramm, V.L., McCluskey, R., Emig, F.A., et al. Kinetic studies and active site-binding properties of glutathione S-transferase using spin-labeled glutathione, a product analogue. J. Biol. Chem. 259(2), 714-722 (1984).
[2]. Zeng, H., Liu, G., Rea, P.A., et al. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. 60(17), 4779-4784 (2000).