8-iso Prostaglandin F2α

An isoprostane that inhibits platelet aggregation

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1mg

￥2787.00

2230.00

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5mg

￥11712.00

9370.00

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10mg

￥20487.00

16390.00

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货号: ajci21272
CAS: 27415-26-5
别名: 8-异前列腺素F2α
分子式: C20H34O5
分子量: 354.5
纯度: >98%
溶解度: DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS pH 7.2: 3 mg/ml
储存: Store at -20°C
库存: 现货

Background

8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.