Diapocynin

An inhibitor of NADPH-oxidase

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库存: 现货

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1mg

￥537.00

430.00

- +
5mg

￥1312.00

1050.00

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10mg

￥2362.00

1890.00

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25mg

￥5137.00

4110.00

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货号: ajci21276
CAS: 29799-22-2
别名:
分子式: C18H18O6
分子量: 330.3
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs). It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A2 (iPLA2) function, and reduces Ca2+ influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy. Diapocynin also reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinson's disease.