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Ilimaquinone

A natural sesquiterpene quinone

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  • 100ug
    ¥3487.00
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  • 货号: ajci21332
  • CAS: 71678-03-0
  • 别名: 3-[(十氢-1Β,2Β,4AΒ-三甲基-5-亚甲基-1-萘基)甲基]-2-羟基-5-甲氧基苯醌
  • 分子式: C22H30O4
  • 分子量: 358.5
  • 纯度: >98%
  • 溶解度: DMSO: Soluble,Ethanol: Soluble,Hexane: Soluble,Methanol: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. In mammalian cells, 25 uM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway. It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 uM). Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 uM, respectively) and, at 10 uM, activates gene expression through hypoxia-inducible factor-1.

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