(±)-2-propyl-4-Pentenoic Acid

A metabolite of valproic acid

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库存: 现货

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10mg

￥537.00

430.00

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25mg

￥1950.00

1560.00

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50mg

￥3387.00

2710.00

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100mg

￥5787.00

4630.00

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货号: ajci21434
CAS: 1575-72-0
别名: 2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA
分子式: C8H14O2
分子量: 142.2
纯度: >98%
溶解度: Slightly soluble in methanol
储存: Store at -20°C
库存: 现货

Background

(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid.[1]? It undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats. 4-ene VPA is also neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos.[2]

Reference:
[1]. Tang, W., and Abbott, F.S. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its α-fluorinated analogue: Phase II metabolism and pharmacokinetics. Drug Metab. Dispos. 25(2), 219-227 (1997).
[2]. Gofflot, F., Nassogne, M.C., Etzion, T., et al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol. Teratol. 17(4), 425-435 (1995).