3-Methylcrotonyl Glycine

A metabolite with diverse biological activities

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10mg

￥612.00

490.00

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50mg

￥2400.00

1920.00

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100mg

￥4462.00

3570.00

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250mg

￥9650.00

7720.00

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货号: ajci21498
CAS: 33008-07-0
别名: N-(3-甲基-1-氧代-2-丁烯基)氨基乙酸
分子式: C7H11NO3
分子量: 157.2
纯度: >98%
溶解度: 50mg/mL in ethanol, 20mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

3-Methylcrotonyl glycine (3-MCG) is a metabolite found in the urine of patients with 3-methylcrotonyl glycinuria, a metabolic disorder characterized by a deficiency in 3-methylcrotonyl-CoA carboxylase, that has diverse biological activities.[1] [2] It inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner.[2] It also inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum, indicating a potential role for this metabolite in the development of CNS damage associated with 3-methycrotonyl glycinuria.

Reference:
[1]. Bartlett, K., Ng, H., and Leonard, J.V. A combined defect of three mitochondrial carboxylases presenting as biotin-responsive 3-methylcrotonyl glycinuria and 3-hydroxyisovaleric aciduria. Clin. Chim. Acta. 100(2), 183-186 (1980).
[2]. Moura, A.P., Ribeiro, C.A., Zanatta, ?., et al. 3-Methylcrotonylglycine disrupts mitochondrial energy homeostasis and inhibits synaptic Na+,K+-ATPase activity in brain of young rats. Cell. Mol. Neurobiol. 32(2), 297-307 (2012).