Debromohymenialdisine

An inhibitor of Chk1 and Chk2

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库存: 现货

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100ug

￥1850.00

1480.00

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货号: ajci21574
CAS: 75593-17-8
别名: DBH, SKF 108753
分子式: C11H11N5O2
分子量: 245.2
纯度: >98%
溶解度: DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2 (IC50 = 3 and 3.5 uM, respectively), blocking G2 arrest. Because it does not significantly affect the activity of ataxia-telangiectasia mutated (ATM) or ATM-Tad2-related protein, DBH is a useful tool for studying the roles of Chk1 and Chk2 in DNA repair and cell cycle regulation. DBH also inhibits MAP kinase kinase 1 (IC50 = 881 nM), glycogen synthase kinase 3β (IC50 = 1.39 μM), cyclin-dependent kinase 5/p25 (IC50 = 9.12 μM), protein tyrosine kinase 6 (IC50 = 0.6 μM), and other kinases largely unrelated to DNA damage/repair and cell cycling.