Lipoxin B4

A positional isomer of LXA4

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
25ug

￥4612.00

3690.00

- +
50ug

￥8762.00

7010.00

- +
100ug

￥16412.00

13130.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci21604
CAS: 98049-69-5
别名: LXB4
分子式: C20H32O5
分子量: 352.5
纯度: >98%
溶解度: DMF: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)
储存: Store at -20°C
库存: 现货

Background

Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.

参考文献:
[1]. Serhan, C.N., Hamberg, M., Samuelsson, B., et al. On the stereochemistry and biosynthesis of lipoxin B Proc. Nat. Acad. Sci. USA 83(7), 1983-1987 (1986).
[2]. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984).
[3]. Papayianni, A., Serhan, C.N., and Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells Journal of Immunology 156, 2264-2272 (1996).