Remogliflozin A

A potent inhibitor of SGLT2

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库存: 现货

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数量
500ug

￥487.00

390.00

- +
1mg

￥912.00

730.00

- +
5mg

￥4212.00

3370.00

- +
10mg

￥7550.00

6040.00

- +

已选 0 种 0 瓶

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货号: ajci21766
CAS: 329045-45-6
别名: Remogliflozin A
分子式: C23H34N2O7
分子量: 450.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Remogliflozin A is a potent inhibitor of sodium-glucose transporter 2 (SGLT2; Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). It is selective for SGLT2 over SGLT1 (Kis = 4,520 and 997 nM for human and rat SGLT1, respectively). Following administration of a prodrug, remogliflozin etabonate, that is rapidly converted to remogliflozin A in vivo, rat urinary glucose excretion increases and plasma glucose and insulin concentrations decrease. Similar effects are observed following oral administration of remogliflozin etabonate to rats with diabetes induced by streptozotocin and db/db mice with hyperinsulinemia and obesity.