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  • AZ82
    AZ82的可视化放大

    AZ82

    An inhibitor of KIFC1

    此产品仅用于科学研究,我们不为任何个人用途提供产品和服务

    AZ82的二维码
    • 库存: 现货
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    • 包装
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      促销价
      数量
    • 1mg
      ¥512.00
      410.00
      - +
    • 5mg
      ¥2825.00
      2260.00
      - +
    • 10mg
      ¥4262.00
      3410.00
      - +
    • 25mg
      ¥8525.00
      6820.00
      - +
    已选 0 0
    金额: ¥0.00
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    • 货号: ajci22154
    • CAS: 1449578-65-7
    • 别名:
    • 分子式: C28H31F3N4O3S
    • 分子量: 560.6
    • 纯度: >98%
    • 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
    • 储存: Store at -20°C
    • 库存: 现货

    Background

    AZ82 is a small molecule inhibitor of KIFC1/HSET, a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes.[1]? AZ82 binds to the KIFC1/microtubule complex and inhibits its microtubule-stimulated activity (IC50 = 300 nM) in an ATP-competitive (Ki = 43 nM) and microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 uM. [2] It is selective for KIFC1 over a panel of nine kinesin motor proteins at a concentration of 5 uM. AZ82 induces multipolar spindle formation in cancer cell lines with high (BT549), but not low (HeLa and MCF-7), numbers of extra chromosomes.


    Reference:
    [1]. Godinho, S.A., and Pellman, D. Causes and consequences of centrosome abnormalities in cancer. Philos. Trans. R. Soc. Lond. B Biol. Sci. 369(1650), pii: 20130467 (2014).
    [2]. Wu, J., Mikule, K., Wang, W., et al. Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. ACS Chem. Biol. 8(10), 2201-2208 (2013).

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