Bexagliflozin

A SGLT2 inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
2mg

￥812.00

650.00

- +
5mg

￥1200.00

960.00

- +
10mg

￥1812.00

1450.00

- +
25mg

￥3600.00

2880.00

- +
50mg

￥5325.00

4260.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci22372
CAS: 1118567-05-7
别名: (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇
分子式: C24H29ClO7
分子量: 464.94
纯度: >98%
溶解度: DMSO : ≥ 100 mg/mL (215.08 mM)
储存: Store at -20°C
库存: 现货

Background

Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 uM /2 nM in SGLT1 /SGLT2 respectively.target: SGLT2IC50: 5.6 uM (SGLT1)/ 2 nM (SGLT2)1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively.2) EGT1442 significantly prolonged the median survival of SHRSP rats.3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.

参考文献:
[1]. Zhang W et al. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. Pharmacol Res. 2011 Apr;63(4):284-93.