Elagolix

An antagonist of GnRHR

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库存: 现货

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促销价

数量
2mg

￥587.00

470.00

- +
5mg

￥912.00

730.00

- +
10mg

￥1350.00

1080.00

- +
50mg

￥4050.00

3240.00

- +
100mg

￥6500.00

5200.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).Target: GnRHin vitro: Elagolix is a short-acting, nonpeptide, GnRH antagonist, administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses. Elagolix is regarded as the frontrunner of a new class of GnRH inhibitors that have been denoted as second-generation, due to their non-peptide nature and oral bioavailability.

参考文献:
[1]. Carr B, et al. Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone acetate for the treatment of endometriosis: effects on bone mineral density. Reprod Sci. 2014 Nov;21(11):1341-1351.