PF-04979064

PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂，对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥687.00

550.00

- +
10mg

￥1225.00

980.00

- +
25mg

￥2462.00

1970.00

- +
50mg

￥4412.00

3530.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

PF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα Ki of 0.13 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM[1].

PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%[1].

参考文献:
[1]. Cheng H et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 2012 Nov 7, 4(1):91-7.