Savolitinib

An inhibitor of c-Met

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库存: 现货

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数量
2mg

￥1100.00

880.00

- +
5mg

￥1737.00

1390.00

- +
10mg

￥2825.00

2260.00

- +
50mg

￥9712.00

7770.00

- +
100mg

￥16562.00

13250.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci22884
CAS: 1313725-88-0
别名: 赛沃替尼; Volitinib; HMPL-504; AZD-6094
分子式: C17H15N9
分子量: 345.36
纯度: >98%
溶解度: DMSO : ≥ 34 mg/mL (98.45 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Savolitinib (AZD6094) ia highly potent and selective c-Met inhibitor with an IC50 of 5 nM.

参考文献:
[1]. Jia H, et al. Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer. J Med Chem. 2014 Sep 25;57(18):7577-89.
[2]. Schuller A, et al. The MET inhibitor AZD6094 (Savolitinib, HMPL-504) induces regression in papillary renal cell carcinoma patient derived xenograft models. Clin Cancer Res. 2015 Mar 16. pii: clincanres.2685.2014.
[3]. Noh CK, et al. Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC-MS/MS for application to a pharmacokinetic study in rats. J Sep Sci. 2017 Jul 27.