SD 0006

An inhibitor of p38α MAPK

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库存: 现货

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1mg

￥425.00

340.00

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5mg

￥1212.00

970.00

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10mg

￥1937.00

1550.00

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25mg

￥3412.00

2730.00

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50mg

￥5750.00

4600.00

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100mg

￥8637.00

6910.00

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货号: ajci22892
CAS: 271576-80-8
别名: 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑,SD-06
分子式: C20H20ClN5O2
分子量: 397.86
纯度: >98%
溶解度: DMSO : ≥ 29 mg/mL (72.89 mM)
储存: Store at -20°C
库存: 现货

Background

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α[1][2].

SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate[1].

SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy[1].SD0006 (3.75, 7.5 and 15 mg/kg; p.o.; b.i.d.) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling[1].

参考文献:
[1]. Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60.
[2]. Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8.