TMB 8 (hydrochloride)

A non-competitive antagonist of nAChRs and an inhibitor of intracellular calcium availability

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库存: 现货

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5mg

￥462.00

370.00

- +
10mg

￥837.00

670.00

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货号: ajci23118
CAS: 53464-72-5
别名: 3,4,5-三甲氧基苯甲酸(8-二乙氨基正辛基)酯盐酸盐
分子式: C22H37NO5 ? HCl
分子量: 432
纯度: >98%
溶解度: Chloroform: Slightly Soluble,Methanol: Slightly Soluble,Water: Slightly Soluble
储存: Store at -20°C
库存: 现货

Background

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM. It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle. TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.