AUT1

A positive modulator of Kv3.1b, Kv3.2a, and Kv3.3

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5mg

￥1300.00

1040.00

- +
25mg

￥4650.00

3720.00

- +

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Background

AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively; displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters; increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM; rescue the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline.

Reference：

[1]. Rosato-Siri MD, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.
[2]. Brown MR, et al. J Neurophysiol. 2016 Jul 1;116(1):106-21.
[3]. Parekh PK, et al. Neuropsychopharmacology. 2018 Jan;43(2):435-444.